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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:BME Seminar: Felipe Quiroz\, PhD
X-WR-TIMEZONE:Central Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260608T060038Z
UID:tag:localist.com\,2008:EventInstance_43888549181582
DTSTART:20231207T160000Z
DTEND:20231207T170000Z
DESCRIPTION:Presenting on “Programming and probing the self-assembly of i
 ntrinsically-disordered proteins”.\n\nFelipe Quiroz\, PhD\, assistant pr
 ofessor of biomedical engineering at Georgia Tech\, will speak on Thursday
 \, Dec. 7\, 2023 at 10 a.m. CST in Whitaker Hall\, room 218.\n\nAbstract: 
 Intrinsically-disordered proteins (IDPs) recently emerged as major drivers
  of self-assembly in nature. Mechanistically\, their stimuli-responsive so
 lubility in aqueous solutions is governed by liquid-liquid phase separatio
 n (LLPS) dynamics. Intracellularly\, for example\, phase-separated IDP-ass
 emblies orchestrate wide-ranging cellular mechanisms\, from genome organiz
 ation to cell division. These bioinspired insights suggest that IDPs are o
 utstanding building blocks for cellular engineering and for the design of 
 self-assembling “smart” materials. In this talk\, I will present our p
 rogress toward programming and probing the LLPS behaviors of intrinsically
 -disordered proteins (IDPs)\, demonstrating their utility as self-assembli
 ng nanomaterials and as scaffolds for engineered organelles. I will highli
 ght our two main approaches: (1) the engineering of lower and upper critic
 al solution temperature LLPS behavior in IDP polymers\; and (2) the develo
 pment of genetically encoded sensors to probe the properties and functiona
 lity of intracellular IDP-assemblies and related biomolecular condensates.
  Dwelling in materials engineering\, I will discuss how the syntax and arc
 hitecture of IDP polymers control their ability to access novel LLPS behav
 iors\, enabling the engineering of IDPs that form highly stable nanopartic
 les. Finally\, I will discuss LLPS-inspired cellular engineering approache
 s for biomedical applications. Overall\, my goal is to demonstrate the seq
 uence-level control of IDP self-assembly as a powerful approach for biomed
 ical engineering innovation.\n\nRegistration is required to attend virtual
 ly. Please register.
GEO:38.649125;-90.303135
LOCATION:Uncas A. Whitaker Hall\, 218
SUMMARY:BME Seminar: Felipe Quiroz\, PhD
URL;VALUE=URI:https://happenings.washu.edu/event/bme_seminar_felipe_quiroz_
 phd
CATEGORIES:Seminar/Colloquia
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