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CATEGORIES:Seminar/Colloquia
DESCRIPTION:Title: Metabolic Nanoscopy for Studying Aging and Diseases\n\nA
 bstract: Understanding metabolism in living organisms is crucial for uncove
 ring the fundamental mechanisms underlying various biological processes. We
  developed the A-PoD and PRM algorithm-assisted multimodal metabolic nanosc
 opy\, which integrates DO-SRS\, MPF\, FLIM\, and SHG into a unified molecul
 ar imaging platform for studying metabolic dynamics in living organisms. Th
 is approach utilizes various deuterated molecules—including glucose\, amino
  acids\, fatty acids\, and water etc. as bioorthogonal metabolic probes. Th
 e enzymatic incorporation of deuterium results in carbon-deuterium (C-D) bo
 nds in newly synthesized molecules\, which can be detected by DO-SRS in the
  Raman spectrum’s spectral cell-silent region\, distinguishing them from ol
 der molecules. This nanoscopy provides novel insights into metabolic hetero
 geneity across different cell types and organ tissues under both physiologi
 cal and pathological conditions. For example\, it revealed that overexpress
 ed tau proteins significantly disrupt lipid metabolism in aged and Alzheime
 r’s-affected brains\, leading to an excessive accumulation of newly formed 
 lipid droplets in glial cells—an effect that can be mitigated by AMPK activ
 ation. This advanced nanoscopy imaging platform holds significant potential
  for disease detection\, diagnosis\, drug discovery\, and evaluating drug e
 fficacy or resistance. It can serve as a tool for understanding the fundame
 ntal mechanisms of aging and disease progression.\n\nBio: Lingyan Shi is cu
 rrently a tenured Associate Professor in the Shu Chien Gene Lay Department 
 of Bioengineering at UCSD. She joined UCSD in 2019\, following her postdoct
 oral training in the Department of Chemistry at Columbia University. Her la
 b at UCSD focuses on developing high-resolution metabolic nanoscopy to stud
 y aging processes and related diseases. Notably\, she discovered the "Golde
 n Window" (1550nm to 1870nm) for deep tissue imaging and pioneered the "DO-
 SRS" metabolic imaging platform\, which visualizes metabolic dynamics in ce
 llular organelles\, and tissues. Her group advanced stimulated Raman scatte
 ring (SRS) microscopy into super-resolution multiplex nanoscopy by developi
 ng A-PoD and PRM algorithms\, revealing various lipid metabolic changes in 
 organ tissues during aging and disease. Dr. Shi holds 10 awarded patents an
 d 14 pending. She won Blavatnik Regional Award for Young Scientists (2018)\
 , Nature Light Science & Applications’ Rising Star Award (2021)\, the Advan
 cing Bioimaging Scialog Fellow Award 2023\, the David L. Williams Lecture S
 cholarship Award (2023)\, the Sloan Research Fellowship in Chemistry (2023)
 \, the BMES-Cellular Molecular Bioengineering Rising Star Faculty Award (20
 24)\, the Davos Summit iCANx Young Scientist Award (2024)\, ICBME Rising St
 ar Award 2024\, and IUPS Young Faculty Award 2024\, Featured in the 2025 Op
 tics notebook\, women in optics\, and selected to be senior member of Natio
 nal Academy of Inventors (NAI).
DTEND:20250321T170000Z
DTSTAMP:20260415T042339Z
DTSTART:20250321T160000Z
GEO:38.648794;-90.30145
LOCATION:Preston M. Green Hall\, Rodin Auditorium\, L0120
SEQUENCE:0
SUMMARY:ESE Seminar Series | Lingyan Shi
UID:tag:localist.com\,2008:EventInstance_48792743330274
URL:https://happenings.washu.edu/event/ese-seminar-series-lingyan-shi
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