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VERSION:2.0
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X-WR-CALNAME:IMSE Seminar: "Supramolecular Biomaterials Enabling Innovation
 s in Cell and Drug Delivery"
X-WR-TIMEZONE:Central Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260911T052555Z
UID:tag:localist.com\,2008:EventInstance_48277534974203
DTSTART:20250414T180000Z
DTEND:20250414T185000Z
DESCRIPTION:Dr. Eric Appel\, Associate Professor of Materials Science and E
 ngineering\, Stanford University\n\nSupramolecular biomaterials exhibit hi
 ghly useful properties that are impossible with traditional materials but 
 crucial for a wide variety of emerging applications in industry or biomedi
 cine. These materials typically employ enthalpy-dominated crosslinking int
 eractions that become more dynamic at elevated temperatures\, leading to s
 ignificant softening. Herein\, we will discuss the development of a supram
 olecular hydrogel platform exploiting dynamic and multivalent interactions
  between biopolymers and nanoparticles that are strongly entropically driv
 en\, providing alternative temperature dependencies than typical for mater
 ials of this type. We will discuss the implications of these crosslinking 
 thermodynamics on the observed mechanical properties\, demonstrating that 
 tuning the thermodynamics and kinetics of these crosslinking interactions 
 enable broad modulation of the mechanical properties of these materials\, 
 including their shear-dependent viscosities\, temperature responsiveness\,
  self-healing\, and cargo encapsulation and controlled release. These mate
 rials exhibit viscous flow under shear stress (shear-thinning) and rapid r
 ecovery of mechanical properties when the applied stress is relaxed (self-
 healing)\, affording facile processing though direct injection or spraying
  approaches\, making then well served for applications in industry and bio
 medicine. Moreover\, the hierarchical construction of these biphasic hydro
 gels enables innovative approaches to formulation and delivery as a divers
 e array of compounds over user-defined timeframes ranging from days to mon
 ths. In one example\, we demonstrate that these unique characteristics can
  be leveraged to generate vaccines exhibiting greatly enhanced magnitude\,
  quality\, and durability of immune responses. In another example\, we dem
 onstrate that these materials can be leveraged for co-delivery of immunost
 imulatory cytokines and CAR-T cells to improve cancer treatments. Overall\
 , this talk will illustrate our recent efforts exploiting dynamic and mult
 ivalent interactions between polymers and nanoparticles to generate hydrog
 el materials exhibiting properties not previously observed in biomaterials
  and affording unique opportunities in industry and biomedicine.\n\nHosted
  by: Dr. Alexandra Rutz
GEO:38.648882;-90.302207
LOCATION:Stephen F. & Camilla T. Brauer Hall\, 12
SUMMARY:IMSE Seminar: "Supramolecular Biomaterials Enabling Innovations in 
 Cell and Drug Delivery"
URL;VALUE=URI:https://happenings.washu.edu/event/imse-seminar-dr-eric-appel
 -stanford-university
CATEGORIES:Seminar/Colloquia
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