MEMS Seminar: “Beyond Flat Fibers: 3D Nanofibrous Microarchitectures for Regenerative Medicine”
Thursday, April 9, 2026 2:30 PM to 3:30 PM
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6548 Forest Park Pkwy, St. Louis, MO 63112, USA
https://mems.washu.edu/index.htmlDr. Johnson V. John, Assistant Professor, Terasaki Institute for Biomedical Innovation, Los Angeles, CA
Abstract: Electrospinning has long been recognized as a versatile platform for fabricating nanofibrous materials with tunable structural, mechanical, and biological properties. Dr. Johnson V. John will present emerging paradigms in nanofiber material design that transcend conventional electrospinning approaches, integrating modularity, biofunctionality, and smart responsiveness for diverse biotechnological and biomedical applications. The talk will explore how 3D electrospun systems are being engineered with hierarchical porosity, anisotropic fiber orientation, and hybrid nanostructures to better mimic native extracellular matrices and modulate cellular behaviors. Dr. John will highlight innovations in porosity-tunable nanofibrous microspheres (NMs) and modular nanofiber composites, designed for injectable wound healing, bone repair, and other tissue regeneration. Special emphasis will be given to the translational dimensions of these materials, ranging from injectable dermal fillers for diabetic wound healing to bioactive dental and bone fillers. By bridging materials science, biofabrication, and clinical translation, this talk will introduce “new dimensions” in electrospun nanofiber design, transforming them from a flat fiber membrane into active, instructive biomaterials that drive regeneration and therapeutic delivery in regenerative medicine.
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